Melanoma Metastases Arising at Unexpected Sites: Gallbladder and Uterus

Although malignant melanoma (MM) most frequently tends to metastasize the regional lymph nodes, liver, lung and brain, several unusual sites of metastasis have been described in literature. Among these, metastatic involvement gallbladder or uterus represents an exceptional event, usually associated with diffuse disease observed as autopsy finding. In this paper, we present two cases isolated MM these anatomic sites, arising a 71-year-old man 54-year-old woman, for whom no information on previous malignancies was known at time histological examination. The clinico-pathologic features are described, emphasizing that must be included differential diagnosis when dealing patients onset novel mass/lesion even sites.